Addressing the gut microbiome's role in health and disease, this session explores microbiota composition, microbial metabolites, and their impact on gastrointestinal disorders. Discussions will cover microbiome-host interactions, probiotic/prebiotic therapies, and microbiome-modulating interventions. The gut microbiome influences digestive function, immune response, and metabolic processes, highlighting its relevance to gastroenterology research. By examining microbiome-related research findings and clinical applications, this session aims to advance understanding of microbial contributions to disease pathogenesis, guide microbiome-targeted therapies, and promote personalized medicine approaches in gastroenterology.