This session explores the continuing global challenge of HIV/AIDS, highlighting progress, persistent gaps, and future directions in prevention, treatment, and care. Experts will discuss advances in antiretroviral therapy, innovative prevention strategies such as PrEP, and the pursuit of an effective HIV vaccine. The session will also address social determinants, stigma, and barriers to equitable access to healthcare that impact vulnerable populations worldwide. By fostering dialogue among researchers, clinicians, policymakers, and community leaders, the session aims to strengthen global efforts toward achieving the UNAIDS 95-95-95 targets and ultimately ending the HIV/AIDS epidemic.