Dr. Hilary Denis Solomons was born on March 28, 1954, in East London, South Africa, where he is also a citizen. He currently resides at 30 Viljoen Street, Rouxville, Johannesburg. With a strong educational background, Dr. Solomons obtained his MB.BCh from the University of Witwatersrand in 1978, followed by a Master of Medicine in Haematology Pathology in 1987. His dissertation focused on platelet aggregation studies and platelet fatty acids in different population groups, supervised by Prof. Peter Atkinson and Prof. Anton Heyns.
Dr. Solomons has amassed considerable experience in the medical field, including locum work in 2016 at various medical centers such as Green Dot Medical Centre and Blue Bird Medical Centre, as well as Biopath Laboratory from February 2008 to December 2015. Prior to 2008, he worked as a locum for several general practitioners, including Dr. Angelo De Bruin and Dr. Stephen Saad. He has also worked in medical casualty at Johannesburg General Hospital, assisting gynecologists with abdominal hysterectomies and caesarean sections.
Fluent in both English and Afrikaans, Dr. Solomons possesses basic computer skills and has personal interests in music, reading, and gym activities. His contributions to the medical community include numerous publications in respected journals, such as the Cardiovascular Journal of Africa and Germs, covering topics ranging from rare syndromes to infectious diseases. Throughout his career, Dr. Solomons has demonstrated a commitment to advancing medical knowledge, particularly in haematology and general medicine, and seeks to continue his practice as a general practitioner.
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Islet cell infusions in the treatment of Diabetes Mellitus .
Diabetes mellitus is a condition characterized by hyperglycinemia due to insufficient release of insulin be the beta cells of the pancreas . The beta cells are located in the islet cells of Langerhans ,
Diabetes is characterized by polyuria , polydipsia and hyperphagia. Diabetes mellitus is characterized by type 2 diabetes which is usually a maturity onset diabetes. Type 1 diabetes is usually insulin dependent and characterized by injection with insulin. Generally speaking type 1 diabetes is more sever and more aggressive. Pancreatic B ( Beta ) cells sense fluctuations in metabolic demand , particularly minute changes in circulating glucose levels. They the uniquely respond by secreting adequate amounts of insulin to regulate glucose homeostasis and metabolism. Diabetes mellitus affects almost every organ of the body . It affects small vessels and larger vessels, Hypercholesterolaemia and threatened digits or limbs may result. Dogs are often used as demonstration models of diabetes. Not to be confused with Diabetes insipidus where inappropriate ADH lead to large volumes of dilute urine. B cells cluster with B cells and endocrine cells of the pancreas to form islets of Langerhans , the endocrine micro-organs of the pancreas . In pancreatic cells and their neighbors and assist B cells to optimize insulin gene expression and islets ,several surface proteins mediate communication among B cells and their neighbors and collectively assist cells to optimize insulin gene expression and insulin content to , as well as inhibit basal, and enhance stimulated insulin secretion. When cultured in conventional 2D platforms , the significantly reduced cell-cell contact disrupts this communication , and consequently C cells lose the ability to properly respond to changing concentrations of insulin secretagogues .
Some people talk about islet cell implantation. The Islet cells are implanted into the portal vein and allowed to seed resulting in copious amounts of functional insulin being produced Diabetic retinopathy is a major cause of blindness worldwide. Several studies indicate that while less characterized , cell contacts and paracrine signaling for normal functioning of pancreatic alpha cells is also important . This necessitates the use of isolated native islets as the go to method for in vitro assessment of pancreatic islet functioning for efficacy and toxicity testing .
Diabetes mellitus is a major cause of disability and morbidity and needs to be totally eradicated. It is my belief that islet cell transfusions in the treatment of diabetes mellitus is the answer to this worldwide pandemic. Immunosuppressive agent may have to be used to prevent host versus graft disease e.g. cyclosporine or imuran . Cortisone use is debatable to prevent graft versus host disease .