Anup Banerjee
Biography
Dr Anup Banerjee passed his primary medical school from Bangladesh in 2017. He worked in Bangladesh as a medical officer in medicine department for four years. He got his GMC registration and license to practice medicine in UK in 2022. Since 2023 he is working as a clinical fellow in Stockport NHS Foundation Trust, UK. He has published numerous case reports in different medical journals indexed by PubMed.
Research Interest
Internal medicine, clinical case reporting, diagnostic challenges, and evidence-based practice in hospital medicine.
Abstract
Severe Neutropenia Due to Carbimazole: Importance of Early Recognition & Management
Background:
Carbimazole, a frontline antithyroid medication, can rarely induce agranulocytosis or severe
neutropenia?potentially life-threatening hematologic complications. Early detection and prompt
intervention are essential to prevent serious outcomes ?.
Case Presentation:
A patient undergoing carbimazole therapy developed profound neutropenia. The diagnosis was
established through comprehensive blood work detecting a significant drop in neutrophils.
Immediate discontinuation of the drug, in addition to supportive measures such as granulocyte
colony-stimulating factor (G-CSF) administration, led to rapid recovery of neutrophil counts.
Regular monitoring allowed timely intervention before severe infection could ensue.
Discussion:
Although carbimazole-induced neutropenia is rare, clinicians must vigilantly monitor complete
blood counts (CBCs) during therapy. Patient education on early warning signs (fever, sore throat)
is critical. This case supports existing literature on the reversibility of hematologic toxicity with
appropriate management ().
Conclusion:
High clinical suspicion, routine CBC monitoring, immediate drug cessation, and supportive
therapies such as G-CSF are key in managing carbimazole-induced severe neutropenia. This
case highlights the importance of early recognition to mitigate morbidity and offers a structured
management algorithm for similar future events.
